Markers not involved in GC tracts either due to no GC event or because GC tracts initiate and terminate between two 2 markers are also informative. gc. Let 1- ? n denote the probability of a GC tract shorter than n nucleotides. Then
Recognition
For a complete dataset with k GC events and t markers not being involved in GC events, the total Likelihood of the data is or its log for convenience. Finally we can obtain numerically the Maximum Likelihood Estimate (MLE) of ? and LGC using the log-likelihood function for our dataset(s). We have applied this approach to estimate ?